Apoptotic DNA fragmentation in tissues of pigs with cardiopulmonary bypass (CPB)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F98%3A00004075" target="_blank" >RIV/00216224:14310/98:00004075 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Apoptotic DNA fragmentation in tissues of pigs with cardiopulmonary bypass (CPB)

Original language description

The goal of this work was to show whether apoptosis would be activated in pigs in the course of cardiopulmonary bypass (CPB), and whether the results obtained on a pig exemplar could be used for the investigation of protection of human myocardium. CPB was carried out by usual procedure on 10 minipigs. Apoptotic cells with extensive DNA fragmentation were found in the bone marrow after chest opening before CPB. This could reflect the reaction of bone marrow to the preoperative stress. After the operationa decrease in the number of nuclei with extensive DNA fragmentation was observed in the tested animals. On the other hand a marked prevalence of bone marrow cells with nuclei with extensive apoptotic fragmentation was found in the dead animals. It was shown that apoptotic DNA fragmentation of myocardial tissue was chiefly all peoved at the end of the operation. However, it was not detected in pulmonary tissues.

Czech name

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Czech description

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Type

B - Specialist book

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/IZ1924" target="_blank" >IZ1924: Postperfusion syndrom II.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

1998

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

ISBN

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Number of pages

1

Publisher name

European Hematology Assotiation - ECDO

Place of publication

Švédsko

UT code for WoS book

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