Dendritic Cell Biology anf the Application of Dendritic Cells to Imunotherapy of Multiple Myeloma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F00%3A00004077" target="_blank" >RIV/00216224:14330/00:00004077 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Dendritic Cell Biology anf the Application of Dendritic Cells to Imunotherapy of Multiple Myeloma

Original language description

Dentritic cells (DCs)are extremely efficient antigen-presenting cells that arepotent stimulators of both B and T cell immune responses. Although DCc are normally present in extremely small numbers in the circulation, recent advances in DC biology have made it possible to generale DCs in culture. DCs can be generated in vitro from various cellular sources including bone marrow, cor blood and peripheral blood. Although culture conditions are extremely diverse, the majority of protocols grow DCs in GM-CSFand either TNF-aplha and/or IL. The addition of other growth factors such as SCF and Flt-3 ligand can dramatically enhance DC recovery. It is important to appereciate that DC subsets have been identified. Thus, DC at different stages of maturation, basedon phenotype and capacity to capture antigen, can be obtained depending on culture conditions. For clinical applications, DCs can be generated in serum-free median and cryopreserved for future cclinical applications. The ability to obtai

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/NC6152" target="_blank" >NC6152: Evaluation of dentritic cells administration in multiple myeloma.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2000

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Medical Oncology

ISSN

1357-0560

e-ISSN

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Volume of the periodical

2000

Issue of the periodical within the volume

17

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

2-15

UT code for WoS article

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EID of the result in the Scopus database

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