Parameter Identification and Model Ranking of Thomas Networks
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F12%3A00057781" target="_blank" >RIV/00216224:14330/12:00057781 - isvavai.cz</a>
Result on the web
<a href="http://link.springer.com/chapter/10.1007/978-3-642-33636-2_13" target="_blank" >http://link.springer.com/chapter/10.1007/978-3-642-33636-2_13</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-642-33636-2_13" target="_blank" >10.1007/978-3-642-33636-2_13</a>
Alternative languages
Result language
angličtina
Original language name
Parameter Identification and Model Ranking of Thomas Networks
Original language description
We propose a new methodology for identification and analysis of discrete gene networks as defined by René Thomas, supported by a tool chain: (i) given a Thomas network with partially known kinetic parameters, we reduce the number of acceptable parametrizations to those that fit time-series measurements and reflect other known constraints by an improved technique of coloured LTL model checking performing efficiently on Thomas networks in distributed environment; (ii) we introduce classification of acceptable parametrizations to identify most optimal ones; (iii) we propose two ways of visualising parametrizations dynamics wrt time-series data. Finally, computational efficiency is evaluated and the methodology is validated on bacteriophage lambda case study.
Czech name
—
Czech description
—
Classification
Type
D - Article in proceedings
CEP classification
IN - Informatics
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/GAP202%2F11%2F0312" target="_blank" >GAP202/11/0312: Software Components in Embedded Systems: Development and Verification</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Computational Methods in Systems Biology: 10th International Conference, CMSB 2012, London, UK, October 3-5, 2012. Proceedings
ISBN
9783642336355
ISSN
0302-9743
e-ISSN
—
Number of pages
20
Pages from-to
207-226
Publisher name
Springer
Place of publication
Berlin
Event location
London
Event date
Jan 1, 2012
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
—