Exploring Parameter Space of Stochastic Biochemical Systems Using Quantitative Model Checking
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F13%3A00066280" target="_blank" >RIV/00216224:14330/13:00066280 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/978-3-642-39799-8_7" target="_blank" >http://dx.doi.org/10.1007/978-3-642-39799-8_7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-642-39799-8_7" target="_blank" >10.1007/978-3-642-39799-8_7</a>
Alternative languages
Result language
angličtina
Original language name
Exploring Parameter Space of Stochastic Biochemical Systems Using Quantitative Model Checking
Original language description
We propose an automated method for exploring kinetic parameters of stochastic biochemical systems. The main question addressed is how the validity of an a priori given hypothesis expressed as a temporal logic property depends on kinetic parameters. Our aim is to compute a landscape function that, for each parameter point from the inspected parameter space, returns the quantitative model checking result for the respective continuous time Markov chain. Since the parameter space is in principle dense, it is infeasible to compute the landscape function directly. Hence, we design an effective method that iteratively approximates the lower and upper bounds of the landscape function with respect to a given accuracy. To this end, we modify the standard uniformization technique and introduce an iterative parameter space decomposition. We also demonstrate our approach on two biologically motivated case studies.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
IN - Informatics
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
25th International Conference, CAV 2013, Saint Petersburg, Russia, July 13-19, 2013. Proceedings
ISBN
9783642397981
ISSN
0302-9743
e-ISSN
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Number of pages
17
Pages from-to
107-123
Publisher name
Springer Berlin Heidelberg
Place of publication
Berlin
Event location
Saint Petersburg
Event date
Jan 1, 2013
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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