Guanine quadruplexes are formed by specific regions of human transposable elements
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F14%3A00077524" target="_blank" >RIV/00216224:14330/14:00077524 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26230/15:PU116955 RIV/68081707:_____/14:00495802
Result on the web
<a href="http://dx.doi.org/10.1186/1471-2164-15-1032" target="_blank" >http://dx.doi.org/10.1186/1471-2164-15-1032</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/1471-2164-15-1032" target="_blank" >10.1186/1471-2164-15-1032</a>
Alternative languages
Result language
angličtina
Original language name
Guanine quadruplexes are formed by specific regions of human transposable elements
Original language description
BACKGROUND:Transposable elements form a significant proportion of eukaryotic genomes. Recently, Lexa et al (Nucleic Acids Res 42:968-978, 2014) reported that plant long terminal repeat (LTR) retrotransposons often contain potential quadruplex sequences (PQSs) in their LTRs and experimentally confirmed their ability to adopt four-stranded DNA conformations.RESULTS:Here, we searched for PQSs in human retrotransposons and found that PQSs are specifically localized in the 3'-UTR of LINE-1 elements, in LTRsof HERV elements and are strongly accumulated in specific regions of SVA elements. Circular dichroism spectroscopy confirmed that most PQSs had adopted monomolecular or bimolecular guanine quadruplex structures. Evolutionarily young SVA elements contained more PQSs than older elements and their propensity to form quadruplex DNA was higher.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BMC Genomics
ISSN
1471-2164
e-ISSN
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Volume of the periodical
15
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
1032
UT code for WoS article
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EID of the result in the Scopus database
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