Quadruplex-forming DNA sequences spread by retrotransposons may serve as genome regulators

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F14%3A00075019" target="_blank" >RIV/00216224:14740/14:00075019 - isvavai.cz</a>

Result on the web

<a href="https://www.landesbioscience.com/journals/mge/article/28084/" target="_blank" >https://www.landesbioscience.com/journals/mge/article/28084/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4161/mge.28084" target="_blank" >10.4161/mge.28084</a>

Result language

angličtina

Original language name

Quadruplex-forming DNA sequences spread by retrotransposons may serve as genome regulators

Original language description

Transposable elements (TEs) are ubiquitous genome inhabitants in eukaryotes. Increasing evidence shows that TEs are involved in regulatory networks of eukaryotic cells and contribute to genome evolution. Recently, we reported that many plant long-terminal repeat (LTR) retrotransposons contain DNA quadruplex-forming sequences at precise positions inside their LTRs and that quadruplexes are better preserved in evolutionary younger elements. As quadruplexes can modulate molecular processes, quadruplexes found at specific distances upstream and downstream from the endogenous TE promoter can affect transcription of the element. Moreover, quadruplexes found in solo LTRs, as well as in 3 ends of 5-truncated copies of LINE-1 elements, can affect expression ofneighboring genes. Here, we propose that this way retrotransposons can serve as vehicles for spread of DNA quadruplexes.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Mobile Genetic Elements

ISSN

2159-256X

e-ISSN

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Volume of the periodical

4

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

4

Pages from-to

"e28084"

UT code for WoS article

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EID of the result in the Scopus database

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