Interactions of Amyloid beta Peptide 1 - 40 and Cerebrosterol

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F12%3A00057234" target="_blank" >RIV/00216224:14740/12:00057234 - isvavai.cz</a>
Alternative codes found
RIV/00023752:_____/12:43913775
Result on the web
<a href="http://www.springerlink.com/content/t5tm1222071x5214/" target="_blank" >http://www.springerlink.com/content/t5tm1222071x5214/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11064-011-0650-8" target="_blank" >10.1007/s11064-011-0650-8</a>

Result language
angličtina
Original language name
Interactions of Amyloid beta Peptide 1 - 40 and Cerebrosterol
Original language description
Amyloid beta peptides appear to play a role in physiological processes; however, they are also involved in the pathogenesis of Alzheimer disease. Their actions under normal conditions are probably mediated by soluble monomeric L-isoforms at low concentrations, perhaps via highly specific interactions. On the contrary, toxic effects of aggregated natural L-isoforms/synthetic D-isoforms on membranes are very similar, but synthetic reverse/random L-isoforms without pronounced aggregation properties are nottoxic. Our previous work reported interactions of non-aggregated/aggregated L-isoforms of amyloid b peptides 1?40/1?42 with racemic 24-hydroxycholesterol.
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
—

Project
<a href="/en/project/GA305%2F09%2F0457" target="_blank" >GA305/09/0457: Evaluation of the binding between cerebrosterol and amyloid beta peptide 1-40</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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