Stereospecific interactions of amyloid ß peptides

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12110%2F10%3A00012125" target="_blank" >RIV/60076658:12110/10:00012125 - isvavai.cz</a>

Alternative codes found

RIV/00023752:_____/10:00001107

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Stereospecific interactions of amyloid ß peptides

Original language description

Although causes of Alzheimer disease are not known yet in a detail, it appears that amyloid ß peptides can play a key role in the pathogenesis of the dementia. The toxicity of peptides is closely associated with their ability to oligomerize and aggregateor to create complexes with various endogenous molecules (e.g., with receptors, carriers, enzymes, oxysterols, etc.). However, mechanisms of their physiological interactions and the shift to pathological effects have not been yet cleared up. The experimental results indicate that the physiological actions of peptides are probably associated with the monomeric soluble L-isoform and mediated by stereospecific binding to corresponding molecule. Synthetic D-isoforms or reverse peptides are not effective here. On the other hand, the toxic actions of aggregated L- and D-isoforms on membranes are very similar. In the study, the complexes of amyloid ß peptides and of R-/S-oxysterols are compared. Possible applications of naturally occurring en

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/GA305%2F09%2F0457" target="_blank" >GA305/09/0457: Evaluation of the binding between cerebrosterol and amyloid beta peptide 1-40</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Psychiatrie

ISSN

1211-7579

e-ISSN

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Volume of the periodical

14

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

4

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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