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Problematic glycosyltransferase Rv3782 from Mycobacterium tuberculosis and its production in new expression system

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F12%3A00060507" target="_blank" >RIV/00216224:14740/12:00060507 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Problematic glycosyltransferase Rv3782 from Mycobacterium tuberculosis and its production in new expression system

  • Original language description

    Mycobacterium tuberculosis is germ causing one of the most difficultly treated and in many cases lethal infectious disease ? tuberculosis. This pathogenic bacterium is characterized by unique cell envelope ? dominant feature of M. tuberculosis and othermycobacterial pathogens and crucial factor of virulence and resistance against toxic insult, such as antibiotics and components of the macrophage's bactericidal arsenal. The synthesis of this mycobacterial cell wall is mediated by dominating group of enzymes ? glycosyltransferases. Rv3782 is mycobacterial glycosyltransferase which is responsible for synthesis of mycobacterial galactan - very important element of mycobacterial cell wall and its lack can cause growth inhibition up to death. Due to its role in the cell wall synthesis, the Rv3782 galactofuranosyltransferase may represent very attractive target for new drug development against tuberculosis.

  • Czech name

  • Czech description

Classification

  • Type

    O - Miscellaneous

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů