Problematic glycosyltransferase Rv3782 from Mycobacterium tuberculosis and its production in new expression system
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F12%3A00060507" target="_blank" >RIV/00216224:14740/12:00060507 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Problematic glycosyltransferase Rv3782 from Mycobacterium tuberculosis and its production in new expression system
Original language description
Mycobacterium tuberculosis is germ causing one of the most difficultly treated and in many cases lethal infectious disease ? tuberculosis. This pathogenic bacterium is characterized by unique cell envelope ? dominant feature of M. tuberculosis and othermycobacterial pathogens and crucial factor of virulence and resistance against toxic insult, such as antibiotics and components of the macrophage's bactericidal arsenal. The synthesis of this mycobacterial cell wall is mediated by dominating group of enzymes ? glycosyltransferases. Rv3782 is mycobacterial glycosyltransferase which is responsible for synthesis of mycobacterial galactan - very important element of mycobacterial cell wall and its lack can cause growth inhibition up to death. Due to its role in the cell wall synthesis, the Rv3782 galactofuranosyltransferase may represent very attractive target for new drug development against tuberculosis.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů