Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F13%3A00066446" target="_blank" >RIV/00216224:14740/13:00066446 - isvavai.cz</a>
Result on the web
<a href="http://rnajournal.cshlp.org/content/early/2013/10/18/rna.040055.113.abstract" target="_blank" >http://rnajournal.cshlp.org/content/early/2013/10/18/rna.040055.113.abstract</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1261/rna.040055.113" target="_blank" >10.1261/rna.040055.113</a>
Alternative languages
Result language
angličtina
Original language name
Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs
Original language description
The mechanisms of gene expression regulation by miRNAs have been extensively studied. However, the regulation of miRNA function and decay has long remained enigmatic. Only recently, 3'uridylation via LIN28A-TUT4/7 has been recognized as an essential component controlling the biogenesis of let-7 miRNAs in stem cells. Although uridylation has been generally implicated in miRNA degradation, the nuclease responsible has remained unknown. Here, we identify the Perlman syndromeassociated protein DIS3L2 as anoligo(U)-binding and processing exoribonuclease that specifically targets uridylated pre-let-7 in vivo. This study establishes DIS3L2 as the missing component of the LIN28-TUT4/7-DIS3L2 pathway required for the repression of let-7 in pluripotent cells.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
RNA
ISSN
1355-8382
e-ISSN
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Volume of the periodical
19
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
1632-1638
UT code for WoS article
000327445700004
EID of the result in the Scopus database
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