Disturbed Default Mode Network Connectivity Patterns in Alzheimer's Disease Associated with Visual Processing

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F14%3A00074326" target="_blank" >RIV/00216224:14740/14:00074326 - isvavai.cz</a>
Result on the web
<a href="https://iospress.metapress.com/content/y7477621420j4145/resource-secured/?target=fulltext.pdf" target="_blank" >https://iospress.metapress.com/content/y7477621420j4145/resource-secured/?target=fulltext.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3233/JAD-131208" target="_blank" >10.3233/JAD-131208</a>

Result language
angličtina
Original language name
Disturbed Default Mode Network Connectivity Patterns in Alzheimer's Disease Associated with Visual Processing
Original language description
Changes in connectivity of the posterior node of the default mode network (DMN) were studied when switching from baseline to a cognitive task using functional magnetic resonance imaging. In all, 15 patients with mild to moderate Alzheimer's disease (AD)and 18 age-, gender-, and education-matched healthy controls (HC) participated in the study. Psychophysiological interactions analysis was used to assess the specific alterations in the DMN connectivity (deactivation-based) due to psychological effects from the complex visual scene encoding task. In HC, we observed task-induced connectivity decreases between the posterior cingulate and middle temporal and occipital visual cortices. These findings imply successful involvement of the ventral visual pathway during the visual processing in our HC cohort. In AD, involvement of the areas engaged in the ventral visual pathway was observed only in a small volume of the right middle temporal gyrus.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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