Default Mode Network Connectivity Patterns associated with Visual Processing at Different Stages of Parkinson's Disease

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F14%3A00074324" target="_blank" >RIV/00216224:14740/14:00074324 - isvavai.cz</a>
Result on the web
<a href="https://iospress.metapress.com/content/e64v6362j4467140/resource-secured/?target=fulltext.pdf" target="_blank" >https://iospress.metapress.com/content/e64v6362j4467140/resource-secured/?target=fulltext.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3233/JAD-132684" target="_blank" >10.3233/JAD-132684</a>

Result language
angličtina
Original language name
Default Mode Network Connectivity Patterns associated with Visual Processing at Different Stages of Parkinson's Disease
Original language description
Background: The default mode network (DMN) decreases its activity when switching from a resting state to a cognitive task condition, while activity of the network engaged in the given task increases. Visual processing is typically disturbed in Parkinson's disease dementia (PDD). Objective: Using functional MRI, we studied the DMN effective connectivity patterns in PDD as compared with cognitively normal patients with Parkinson's disease (PD) and healthy controls (HC) when switching from baseline to a visual cognitive task condition. Methods: In all, 14 PDD, 18 PD, and 18 age-matched healthy controls participated in this functional MRI study. We used a psychophysiological interaction analysis with the precuneus (PCu) as a seed. The threshold was set atp(FWE) <0.05. Results: The healthy controls showed greater PCu connectivity with the bilateral middle temporal/middle occipital gyri at baseline than during the task condition. The correlation direction changed from positive to negativ
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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