Structure and Genome Release Mechanism of the Human Cardiovirus Saffold Virus 3

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F16%3A00093713" target="_blank" >RIV/00216224:14740/16:00093713 - isvavai.cz</a>
Alternative codes found
RIV/00027162:_____/16:N0000151
Result on the web
<a href="http://jvi.asm.org/content/90/17/7628" target="_blank" >http://jvi.asm.org/content/90/17/7628</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1128/JVI.00746-16" target="_blank" >10.1128/JVI.00746-16</a>

Result language
angličtina
Original language name
Structure and Genome Release Mechanism of the Human Cardiovirus Saffold Virus 3
Original language description
In order to initiate an infection, viruses need to deliver their genomes into cells. This involves uncoating the genome and transporting it to the cytoplasm. The process of genome delivery is not well understood for nonenveloped viruses. We address this gap in our current knowledge by studying the uncoating of the nonenveloped human cardiovirus Saffold virus 3 (SAFV-3) of the family Picornaviridae. SAFVs cause diseases ranging from gastrointestinal disorders to meningitis. We present a structure of a native SAFV-3 virion determined to 2.5 angstrom by X-ray crystallography and an 11-angstrom-resolution cryo-electron microscopy reconstruction of an "altered" particle that is primed for genome release. The altered particles are expanded relative to the native virus and contain pores in the capsid that might serve as channels for the release of VP4 subunits, N termini of VP1, and the RNA genome.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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