Formulation Development, Physicochemical Characterization and In Vitro-In Vivo Drug Release of Vaginal Films
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F16%3A00093893" target="_blank" >RIV/00216224:14740/16:00093893 - isvavai.cz</a>
Result on the web
<a href="http://www.eurekaselect.com/136942/article" target="_blank" >http://www.eurekaselect.com/136942/article</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1570162X14666151113123040" target="_blank" >10.2174/1570162X14666151113123040</a>
Alternative languages
Result language
angličtina
Original language name
Formulation Development, Physicochemical Characterization and In Vitro-In Vivo Drug Release of Vaginal Films
Original language description
Purpose: The purpose of this study was formulation and optimization of vaginal film formulation containing abacavir (ABC), a potent nucleoside reverse transcriptase inhibitor. Methods: Vaginal films were prepared by solvent evaporation method using hydroxypropyl methylcellulose (HPMC) blended with polyvinyl pyrrolidone (PVP). Various physicochemical parameters of the prepared films such as drug content, thickness, tensile strength, percentage elongation at break, drug polymer interaction, swelling capacity, folding endurance, bio-adhesion, pH, and moisture content were evaluated with morphological studies. In vitro release study and in vivo release study were also performed. Results: Films exhibited favorable physicochemical properties. The in vitro study showed that HPMC-PVP combination can control the release of abacavir through vaginal films with higher amount of PVP in the formulation resulting in an enhanced drug release rate.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
—
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
CURRENT HIV RESEARCH
ISSN
1570-162X
e-ISSN
—
Volume of the periodical
14
Issue of the periodical within the volume
4
Country of publishing house
AE - UNITED ARAB EMIRATES
Number of pages
12
Pages from-to
295-306
UT code for WoS article
000378058100001
EID of the result in the Scopus database
—