The GlcNAc-TV Glycosyltransferase Homology Model Strucutre
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F16%3A00093901" target="_blank" >RIV/00216224:14740/16:00093901 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The GlcNAc-TV Glycosyltransferase Homology Model Strucutre
Original language description
Structural diversity of complex-type N-linked oligosaccharides begins with GlcNAc branching of the trimannosyl core by the glycosyltransferase GlcNAc-TV. The enzyme UDP-N-acetylglucosamine: alpha-D-mannoside beta-1-6 N-acetylglucosaminyltransferase V (GnT-V) catalyzes the transfer of GlcNAc from the UDP-GlcNAc donor to the alpha-1-6-linked mannose of the trimannosyl core structure of glycoproteins to produce the beta-1-6-linked branching of N-linked oligosaccharides. The transfer occurs with inversion of the anomeric configuration and is metal-ion-independent. The creation of the beta-1-6- linkage is crucial for further elongation of the carbohydrate chains of N-glycans and biosynthesis of polylactosamine chains terminating with various sequences, including Lewis antigens. beta-1-6-GlcNAc-branched N-glycans are associated with cancer growth and metastasis. Therefore, the inhibition of GnT-V represents a key target for anti-cancer drug development.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů