Antigen receptor repertoire profiling from RNA-seq data

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F17%3A00100350" target="_blank" >RIV/00216224:14740/17:00100350 - isvavai.cz</a>

Result on the web

<a href="https://www.nature.com/articles/nbt.3979" target="_blank" >https://www.nature.com/articles/nbt.3979</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/nbt.3979" target="_blank" >10.1038/nbt.3979</a>

Result language

angličtina

Original language name

Antigen receptor repertoire profiling from RNA-seq data

Original language description

Somatic recombination and accumulation of mutations in V-D-J segments result in vast heterogeneity of T-cell receptor (TCR) and immunoglobulin repertoires1,2. High-throughput profiling of immune receptors has become an important tool for studies of adaptive immunity and for the development of diagnostics, vaccines, and immunotherapies3,4,5,6,7. There are efficient molecular and software tools for the targeted sequencing of TCR and immunoglobulin repertoires6,8, including MiXCR, developed by our team9. However, sufficient amount and quality of tissue or extracted RNA or DNA are not always available for analysis.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10600 - Biological sciences

Project

—

Continuities

R - Projekt Ramcoveho programu EK

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature biotechnology

ISSN

1087-0156

e-ISSN

—

Volume of the periodical

35

Issue of the periodical within the volume

10

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

908-911

UT code for WoS article

000412764600010

EID of the result in the Scopus database

2-s2.0-85031088639