Quantitative profiling reveals minor changes of T cell receptor repertoire in response to subunit inactivated influenza vaccine
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F18%3A00106653" target="_blank" >RIV/00216224:14740/18:00106653 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.vaccine.2018.02.027" target="_blank" >http://dx.doi.org/10.1016/j.vaccine.2018.02.027</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.vaccine.2018.02.027" target="_blank" >10.1016/j.vaccine.2018.02.027</a>
Alternative languages
Result language
angličtina
Original language name
Quantitative profiling reveals minor changes of T cell receptor repertoire in response to subunit inactivated influenza vaccine
Original language description
Vaccination against influenza is widely used to protect against seasonal flu epidemic although its effectiveness is debated. Here we performed deep quantitative T cell receptor repertoire profiling in peripheral blood of a healthy volunteer in response to trivalent subunit influenza vaccine. We did not observe significant rebuilding of peripheral blood T cell receptors composition in response to vaccination. However, we found several clonotypes in memory T cell fraction that were undetectable before the vaccination and had a maximum concentration at day 45 after vaccine administration. These cells were found in lower concentration in the course of repertoire monitoring for two years period. Our observation suggests a potential for recruitment of only a limited number of new T cells after each seasonal influenza vaccination. (C) 2018 Elsevier Ltd. All rights reserved.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Vaccine
ISSN
0264-410X
e-ISSN
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Volume of the periodical
36
Issue of the periodical within the volume
12
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
1599-1605
UT code for WoS article
000427669700015
EID of the result in the Scopus database
2-s2.0-85042026136