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Quantitative profiling reveals minor changes of T cell receptor repertoire in response to subunit inactivated influenza vaccine

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F18%3A00106653" target="_blank" >RIV/00216224:14740/18:00106653 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.vaccine.2018.02.027" target="_blank" >http://dx.doi.org/10.1016/j.vaccine.2018.02.027</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.vaccine.2018.02.027" target="_blank" >10.1016/j.vaccine.2018.02.027</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Quantitative profiling reveals minor changes of T cell receptor repertoire in response to subunit inactivated influenza vaccine

  • Original language description

    Vaccination against influenza is widely used to protect against seasonal flu epidemic although its effectiveness is debated. Here we performed deep quantitative T cell receptor repertoire profiling in peripheral blood of a healthy volunteer in response to trivalent subunit influenza vaccine. We did not observe significant rebuilding of peripheral blood T cell receptors composition in response to vaccination. However, we found several clonotypes in memory T cell fraction that were undetectable before the vaccination and had a maximum concentration at day 45 after vaccine administration. These cells were found in lower concentration in the course of repertoire monitoring for two years period. Our observation suggests a potential for recruitment of only a limited number of new T cells after each seasonal influenza vaccination. (C) 2018 Elsevier Ltd. All rights reserved.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30102 - Immunology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Vaccine

  • ISSN

    0264-410X

  • e-ISSN

  • Volume of the periodical

    36

  • Issue of the periodical within the volume

    12

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    7

  • Pages from-to

    1599-1605

  • UT code for WoS article

    000427669700015

  • EID of the result in the Scopus database

    2-s2.0-85042026136