Is IL-1 beta Further Evidence for the Role of Propionibacterium acnes in Degenerative Disc Disease? Lessons From the Study of the Inflammatory Skin Condition Acne Vulgaris
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F18%3A00106680" target="_blank" >RIV/00216224:14740/18:00106680 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3389/fcimb.2018.00272" target="_blank" >http://dx.doi.org/10.3389/fcimb.2018.00272</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fcimb.2018.00272" target="_blank" >10.3389/fcimb.2018.00272</a>
Alternative languages
Result language
angličtina
Original language name
Is IL-1 beta Further Evidence for the Role of Propionibacterium acnes in Degenerative Disc Disease? Lessons From the Study of the Inflammatory Skin Condition Acne Vulgaris
Original language description
The pathogenesis of degenerative disc disease is a complex and multifactorial process in which genetics, mechanical trauma, altered loading and nutrition present significant etiological factors. Infection of the intervertebral disc with the anaerobic bacterium Propionibacteriumacnes is now also emerging as a potentially new etiological factor. This human commensal bacterium is well known for its long association with the inflammatory skin condition acne vulgaris. A key component of inflammatory responses to P. acnes in acne appears to be interleukin (IL)-1 beta. Similarly, in degenerative disc disease (DDD) there is compelling evidence for the fundamental roles of IL-1 beta in its pathology. We therefore propose that P. acnes involvement in DDD is biologically very plausible, and that IL-1 beta is the key inflammatory mechanism driving the host response to P. acnes infection. Since there is a solid theoretical basis for this phenomenon, we further propose that the relationship between P. acnes infection and DDD is causal.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
ISSN
2235-2988
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
AUG
Country of publishing house
CH - SWITZERLAND
Number of pages
7
Pages from-to
272
UT code for WoS article
000441660900001
EID of the result in the Scopus database
2-s2.0-85052298313