Fast In Vivo High-Resolution Diffusion MRI of the Human Cervical Spinal Cord Microstructure
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F19%3A00108610" target="_blank" >RIV/00216224:14740/19:00108610 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26220/19:PU129071
Result on the web
<a href="http://dx.doi.org/10.1007/978-981-10-9035-6_1" target="_blank" >http://dx.doi.org/10.1007/978-981-10-9035-6_1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-981-10-9035-6_1" target="_blank" >10.1007/978-981-10-9035-6_1</a>
Alternative languages
Result language
angličtina
Original language name
Fast In Vivo High-Resolution Diffusion MRI of the Human Cervical Spinal Cord Microstructure
Original language description
Diffusion Magnetic Resonance Imaging (dMRI) is a widely-utilized method for assessment of microstructural properties in the central nervous system i.e., the brain and spinal cord (SC). In the SC, almost all previous human studies utilized Diffusion Tensor Imaging (DTI), which cannot accurately model areas where white matter (WM) pathways cross or diverge. While High Angular Diffusion Resolution Imaging (HARDI) can overcome some of these limitations, longer acquisition times critically limit its applicability to clinical human studies. In addition, previous human HARDI studies have used limited spatial resolution, with typically a few slices and voxel size similar to 1 x 1 x 5 mm(3) being acquired in tens of minutes. Thus, we have optimized a novel fast HARDI protocol that allows collecting dMRI data at high angular and spatial resolutions in clinically-feasible time. Our data was acquired, using a 3T Siemens Prisma scanner, in less than 9 min. It has a total of 75 diffusion-weighted volumes and high spatial resolution of 0.67 x 0.67 x 3 mm(3) (after interpolation in Fourier space) covering the cervical segments C4-C6. Our preliminary results demonstrate applicability of our technique in healthy individuals with good correspondence between low fractional anisotropy (FA) gray matter areas from the dMRI scans, and the same regions delineated on T2-weighted MR images with spatial resolution of 0.35 x 0.35 x 2.5 mm(3). Our data also allows the detection of crossing fibers that were previously shown in vivo only in animal studies.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
WORLD CONGRESS ON MEDICAL PHYSICS AND BIOMEDICAL ENGINEERING 2018, VOL 1
ISBN
9789811090356
ISSN
1680-0737
e-ISSN
—
Number of pages
5
Pages from-to
3-7
Publisher name
SPRINGER
Place of publication
NEW YORK
Event location
Praha
Event date
Jan 1, 2019
Type of event by nationality
CST - Celostátní akce
UT code for WoS article
000450908300001