Fast In Vivo High-Resolution Diffusion MRI of the Human Cervical Spinal Cord Microstructure
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F19%3APU129071" target="_blank" >RIV/00216305:26220/19:PU129071 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/19:00108610
Result on the web
<a href="https://link.springer.com/chapter/10.1007/978-981-10-9035-6_1" target="_blank" >https://link.springer.com/chapter/10.1007/978-981-10-9035-6_1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-981-10-9035-6_1" target="_blank" >10.1007/978-981-10-9035-6_1</a>
Alternative languages
Result language
angličtina
Original language name
Fast In Vivo High-Resolution Diffusion MRI of the Human Cervical Spinal Cord Microstructure
Original language description
Diffusion Magnetic Resonance Imaging (dMRI) is a widely-utilized method for assessment of microstructural properties in the central nervous system i.e., the brain and spinal cord (SC). In the SC, almost all previous human studies utilized Diffusion Tensor Imaging (DTI), which cannot accurately model areas where white matter (WM) pathways cross or diverge. While High Angular Diffusion Resolution Imaging (HARDI) can overcome some of these limitations, longer acquisition times critically limit its applicability to clinical human studies. In addition, previous human HARDI studies have used limited spatial resolution, with typically a few slices and voxel size 1 x 1 x 5 mm3 being acquired in tens of minutes. Thus, we have optimized a novel fast HARDI protocol that allows collecting dMRI data at high angular and spatial resolutions in clinically-feasible time. Our data was acquired, using a 3T Siemens Prisma scanner, in less than 9 min. It has a total of 75 diffusion-weighted volumes and high spatial resolution of 0.67 x 0.67 x 3 mm3 (after interpolation in Fourier space) covering the cervical segments C4–C6. Our preliminary results demonstrate applicability of our technique in healthy individuals with good correspondence between low fractional anisotropy (FA) gray matter areas from the dMRI scans, and the same regions delineated on T2-weighted MR images with spatial resolution of 0.35 x 0.35 x 2.5 mm3. Our data also allows the detection of crossing fibers that were previously shown in vivo only in animal studies.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
20601 - Medical engineering
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
World Congress on Medical Physics and Biomedical Engineering 2018
ISBN
978-981-10-9034-9
ISSN
1680-0737
e-ISSN
—
Number of pages
5
Pages from-to
3-7
Publisher name
Springer, Singapore
Place of publication
Neuveden
Event location
Prague
Event date
Jun 3, 2018
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000450908300001