Translation machinery captured in motion

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F23%3A00130801" target="_blank" >RIV/00216224:14740/23:00130801 - isvavai.cz</a>
Result on the web
<a href="https://wires.onlinelibrary.wiley.com/doi/10.1002/wrna.1792" target="_blank" >https://wires.onlinelibrary.wiley.com/doi/10.1002/wrna.1792</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/wrna.1792" target="_blank" >10.1002/wrna.1792</a>

Result language
angličtina
Original language name
Translation machinery captured in motion
Original language description
Translation accuracy is one of the most critical factors for protein synthesis. It is regulated by the ribosome and its dynamic behavior, along with translation factors that direct ribosome rearrangements to make translation a uniform process. Earlier structural studies of the ribosome complex with arrested translation factors laid the foundation for an understanding of ribosome dynamics and the translation process as such. Recent technological advances in time-resolved and ensemble cryo-EM have made it possible to study translation in real time at high resolution. These methods provided a detailed view of translation in bacteria for all three phases: initiation, elongation, and termination. In this review, we focus on translation factors (in some cases GTP activation) and their ability to monitor and respond to ribosome organization to enable efficient and accurate translation.This article is categorized under:Translation > Ribosome Structure/FunctionTranslation > Mechanisms
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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