Application of long-read sequencing for detection of complex chromosomal rearrangements.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F23%3A00131783" target="_blank" >RIV/00216224:14740/23:00131783 - isvavai.cz</a>
Result on the web
<a href="https://ssbmb2023.sk/" target="_blank" >https://ssbmb2023.sk/</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Application of long-read sequencing for detection of complex chromosomal rearrangements.
Original language description
Complex karyotype (CK) typically involves various, often extensive numerical and structural chromosomal abnormalities. In chronic lymphocytic leukemia (CLL), it represents an established biomarker of adverse outcome. Common methods to detect CK include classical cytogenetics and genomic microarray; additional information may be obtained using next generation sequencing (NGS). However, all these approaches show low accuracy and sensitivity for detecting complex structural variants at the DNA sequence level. We aimed to explore the ability of long-read sequencing for the precise characterization of complex genomic variants in CLL patient samples.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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