The Thermodynamic Dissociation Constants of Azathioprine by the Nonlinear Regression and Factor Analysis of Multiwavelength Spectrophotometric pH-Titration Data

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F10%3A39881669" target="_blank" >RIV/00216275:25310/10:39881669 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The Thermodynamic Dissociation Constants of Azathioprine by the Nonlinear Regression and Factor Analysis of Multiwavelength Spectrophotometric pH-Titration Data
Original language description
The mixed dissociation constant of azathioprine at various ionic strengths I , and at temperatures of 25? and 37?, was determined with the use of two different multiwavelength and multivariate treatments of spectral data, SPECFIT32 and SQUAD(84) nonlinear regression analyses and INDICES factor analysis according to a general rule. First, the number of components is determined, and then the spectral responses and concentrations of the components are calculated. The factor analysis in the INDICES programme predicts the correct number of two light-absorbing species L{sup}-{/sup} and HL. The thermodynamic dissociation constant pK{sub}T{/sub}{sup}a{/sup} of azathioprine was estimated by nonlinear regression of {pK{sup}a{/sup}, I} data, pK{sub}T{/sub}{sup}a{/sup} = 8.07(1) at 25? and 7.84(1) at 37?, where the figure in brackets is the standard deviation in last significant digits.
Czech name
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Czech description
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Project
<a href="/en/project/NS9831" target="_blank" >NS9831: Optimization of laboratory examinations in endocrinology using multivariate statistics</a>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP) Z - Vyzkumny zamer (s odkazem do CEZ) S - Specificky vyzkum na vysokych skolach

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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