Dissociation Enthalpies and Thermodynamic Constants of Sildenafil Citrate by the Regression of Multiwavelength pH-spectrophotometric Titration Data

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F12%3A39895068" target="_blank" >RIV/00216275:25310/12:39895068 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s10953-012-9929-x" target="_blank" >http://dx.doi.org/10.1007/s10953-012-9929-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10953-012-9929-x" target="_blank" >10.1007/s10953-012-9929-x</a>

Result language
angličtina
Original language name
Dissociation Enthalpies and Thermodynamic Constants of Sildenafil Citrate by the Regression of Multiwavelength pH-spectrophotometric Titration Data
Original language description
pH-spectrophotometric titration data were used to determine the mixed dissociation constants of sildenafil citrate at different ionic strengths I at temperatures of 288.15, 298.15 and 310.15 K, with the use of two different multiwavelength and multivariate treatments of spectral data, SPECFIT32 and SQUAD(84) nonlinear regression analyses, and INDICES factor analysis. The reliability of the dissociation constants of this drug was proven with goodness-of-fit tests of the pH-spectra. The thermodynamic dissociation constants were estimated by a nonlinear regression of (pK (a) , I) data using the Debye-Huckel equation: pKTa1= 2.79 (1), 3.03 (3) and 3.53 (1);pKTa2 = 4.97 (2), 5.23 (2) and 5.34 (1);pKTa3 = 8.14 (2), 7.93 (1) and 7.47 (1);pKTa4 = 9.47 (2), 9.30 (1) and 9.13 (4); and pKTa5= 10.73 (5), 10.75 (3) and 10.79 (5) at T = 288.15, 298.15 and 310.15 K, respectively, where the numbers in parentheses are the standard deviations in the last significant digits. Concurrently, the experimenta
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Project
<a href="/en/project/NS9831" target="_blank" >NS9831: Optimization of laboratory examinations in endocrinology using multivariate statistics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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