New derivatives of salicylamides: Preparation and antimicrobial activity against various bacterial species

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F13%3A39896495" target="_blank" >RIV/00216275:25310/13:39896495 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/13:10145618 RIV/62157124:16170/13:43872135 RIV/62157124:16370/13:43872135 RIV/62157124:16810/13:43872135
Result on the web
<a href="http://dx.doi.org/10.1016/j.bmc.2013.08.029" target="_blank" >http://dx.doi.org/10.1016/j.bmc.2013.08.029</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bmc.2013.08.029" target="_blank" >10.1016/j.bmc.2013.08.029</a>

Result language
angličtina
Original language name
New derivatives of salicylamides: Preparation and antimicrobial activity against various bacterial species
Original language description
Three series of salicylanilides, esters of N-phenylsalicylamides and 2-hydroxy-N-[1-(2-hydroxyphenylamino)-1-oxoalkan-2-yl]benzamides, in total thirty target compounds were synthesized and characterized. The compounds were evaluated against seven bacterial and three mycobacterial strains. The antimicrobial activities of some compounds were comparable or higher than the standards ampicillin, cipro?oxacin or isoniazid. Derivatives 3f demonstrated high biological activity against Staphylococcus aureus (60.03 lmol/L), Mycobacterium marinum (60.40 lmol/L) and Mycobacterium kansasii (1.58 lmol/L), 3g shows activity against Clostridium perfringens (60.03 lmol/L) and Bacillus cereus (0.09 lmol/L), 3h against Pasteurella multocida (60.03 lmol/L) and M. kansasii(60.43 lmol/L), 3i against methicillin-resistant S. aureus and B. cereus (60.03 lmol/L). The structure?activity relationships are discussed for all the compounds.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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