Sensitive voltammetric method for determination of chemotherapeutic drug methotrexate using liquid mercury free silver solid amalgam electrode

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F14%3A39898015" target="_blank" >RIV/00216275:25310/14:39898015 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Sensitive voltammetric method for determination of chemotherapeutic drug methotrexate using liquid mercury free silver solid amalgam electrode

Original language description

Voltammetric behavior of a wide-spread used chemotherapeutic drug methotrexate (MTX) has been investigated on a polished silver solid amalgam electrode (p-AgSAE) employing various voltammetric methods like cyclic voltammetry, direct current voltammetry and differential pulse voltammetry. It was found that MTX provided two reduction and one oxidation peak in an acidic medium and the positively situated reduction signal (Ep = -340 mV), due its favorable analytical properties, was studied more in detail. 0.05 mol L-1 acetate buffer of pH 5 was selected as an optimal medium for monitoring of the MTX reduction on p-AgSAE. Operating parameters of differential pulse voltammetry were optimized and proposed voltammetric method provided high repeatability (relative standard deviation of 11 repeated measurements at concentration level of methotrexate of 1x10-7 mol L-1 equaled to 1.7%), linear concentration range from 5x10-10 to 3x10-6 mol L-1 and low limit of detection (LD = 1.5x10-10 mol L-1). T

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CG - Electrochemistry

OECD FORD branch

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Project

<a href="/en/project/EE2.3.30.0021" target="_blank" >EE2.3.30.0021: Strenthening of Research and Development Teams at the University of Pardubice</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scientific Papers of the University of Pardubice, Series A, Faculty of Chemical Technology

ISSN

1211-5541

e-ISSN

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Volume of the periodical

20

Issue of the periodical within the volume

září 2014

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

16

Pages from-to

131-146

UT code for WoS article

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EID of the result in the Scopus database

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