Sensitive Voltammetric Sensor Based on Boron-Doped Diamond Electrode for Determination of the Chemotherapeutic Drug Methotrexate in Pharmaceutical and Biological Samples

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F15%3A39900150" target="_blank" >RIV/00216275:25310/15:39900150 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1002/elan.201400326" target="_blank" >http://dx.doi.org/10.1002/elan.201400326</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/elan.201400326" target="_blank" >10.1002/elan.201400326</a>

Result language

angličtina

Original language name

Sensitive Voltammetric Sensor Based on Boron-Doped Diamond Electrode for Determination of the Chemotherapeutic Drug Methotrexate in Pharmaceutical and Biological Samples

Original language description

A novel sensitive voltammetric method for the determination of an important chemotherapeutic drug, methotrexate, was designed using a bare boron-doped diamond electrode in connection with differential pulse voltammetry. Methotrexate provided one well developed oxidation peak suitable for analytical purposes at about + 1000 mV (vs. Ag/AgCl electrode) in an acidic medium. The voltammetric behavior of methotrexate in dependence of pH of the supporting electrolyte and scan rate has been investigated using cyclic voltammetry and DC voltammetry, respectively, to select the suitable experimental parameters. The optimum conditions for its determination using differential pulse voltammetry have been found to be 0.05 mol L-1 H2SO4 with a limit of detection of 1.0 x 10(-8) mol L-1 and a linear dynamic range from 5 x 10(-8) to 2 x 10(-5) mol L-1. Calculated values of relative standard deviations of repeated determinations (n }= 5) in various concentration levels of methotrexate did not exceed 4%.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

<a href="/en/project/EE2.3.30.0021" target="_blank" >EE2.3.30.0021: Strenthening of Research and Development Teams at the University of Pardubice</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Electroanalysis

ISSN

1040-0397

e-ISSN

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Volume of the periodical

27

Issue of the periodical within the volume

1

Country of publishing house

DE - GERMANY

Number of pages

10

Pages from-to

42-51

UT code for WoS article

000347838300006

EID of the result in the Scopus database

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