Comprehensive two-dimensional liquid chromatography - mass spectrometry for lipidomic analysis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F14%3A39899333" target="_blank" >RIV/00216275:25310/14:39899333 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Comprehensive two-dimensional liquid chromatography - mass spectrometry for lipidomic analysis
Original language description
Lipids have numerous important functions in cells, tissues and body fluids, such as the formation of lipid bilayer, cell signaling, energy storage, etc. Lipidomics is a subset of metabolomics, which is aimed on the complex analysis of cellular lipid molecules isolated from cells, tissues or biological fluids and their biological roles with respect to health and disease states. Lipidomics contribute to the understanding how lipids work in a biological system (cellular physiology and pathology) [1]. One part of this work is focused on off-line two-dimensional liquid chromatography - mass spectrometry (2D-LC/MS) analysis of plasma samples, where the total lipid extract of plasma was separated into individual fractions of polar and nonpolar lipid classes.In the first dimension, 6 classes of polar lipids and 3 classes of nonpolar lipids were isolated by hydrophilic liquid chromatography (HILIC), where compounds are separated according to their polarity. Individual fractions were subsequent
Czech name
—
Czech description
—

Project
<a href="/en/project/LL1302" target="_blank" >LL1302: Mass Spectrometry in Cancer Research: Lipid Biomarkers for Early Diagnostics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)