Long-term stability of cancer biomarkers in human serum: biomarkers of oxidative stress and redox status, homocysteine, CRP and the enzymes ALT and GGT
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F15%3A39899905" target="_blank" >RIV/00216275:25310/15:39899905 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.2217/bmm.15.14" target="_blank" >http://dx.doi.org/10.2217/bmm.15.14</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2217/bmm.15.14" target="_blank" >10.2217/bmm.15.14</a>
Alternative languages
Result language
angličtina
Original language name
Long-term stability of cancer biomarkers in human serum: biomarkers of oxidative stress and redox status, homocysteine, CRP and the enzymes ALT and GGT
Original language description
Aim: Five frequently used biomarkers in cancer research and epidemiological studies were tested for their assay stability upon storage of serum for 12 months at -20 and -70/-80 degrees C. Materials & methods: The biomarker assays include reactive oxygenmetabolites (ROM), the total thiol levels (TTL), homocysteine (HCy), C-reactive protein (HS-CRP) and two liver enzymes, alanine aminotransferase (ALT) and -glutamyltransferase (GGT). Results: The assays for ROM, HCy, HS-CRP and GGT were stable in human serum samples at the two temperatures tested. The two other assays TTL and ALT, however, showed statistically significant differences in their stability between -20 and -80 degrees C. Conclusion: Therefore, storage at -80 degrees C is advised to maintaina reliable assay outcome when serum samples have to be stored for longer periods.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomarkers in Medicine
ISSN
1752-0363
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
5
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
425-432
UT code for WoS article
000354647700004
EID of the result in the Scopus database
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