Highly Water-Soluble Cyclopentadienyl and Indenyl Molybdenum(II) Complexes - Second Generation of Molybdenum-Based Cytotoxic Agents
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F16%3A39901700" target="_blank" >RIV/00216275:25310/16:39901700 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/16:10322420
Result on the web
<a href="http://dx.doi.org/10.1002/ejic.201501133" target="_blank" >http://dx.doi.org/10.1002/ejic.201501133</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ejic.201501133" target="_blank" >10.1002/ejic.201501133</a>
Alternative languages
Result language
angličtina
Original language name
Highly Water-Soluble Cyclopentadienyl and Indenyl Molybdenum(II) Complexes - Second Generation of Molybdenum-Based Cytotoxic Agents
Original language description
A series of the cyclopentadienyl and indenyl molybdenum compounds bearing alkylammonium functions [(eta(5)-Cp')Mo(CO)(2)(L-N,L-N)][BF4](2) were synthesized and characterized by analytical and spectroscopic methods. The structures of [{eta(5)-C5H4CH2CH2NH(CH2)(5)}Mo(CO)(2)(4,7-Ph-2-phen)][BF4](2) (4,7-Ph-2-phen = 4,7-dipheny1-1,10-phenanthroline) and [(eta(5)-C9H6CH2CH2NHMe2)Mo(CO)(2)(phen)][BF4](2) (phen = 1,10-phenanthroline) were determined by X-ray crystallography. All of the synthesized compounds exhibit high activity against the human leukemia cell lines MOLT-4 and HL-60. They are approximately one order of magnitude more active than cisplatin. This study has proven that the modification of the outer coordination sphere of molybdenum complexes has a strong impact on their activity and may be successfully used for the design of new highly cytotoxic active species.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Inorganic Chemistry
ISSN
1434-1948
e-ISSN
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Volume of the periodical
Neuveden
Issue of the periodical within the volume
4
Country of publishing house
DE - GERMANY
Number of pages
11
Pages from-to
519-529
UT code for WoS article
000370352400009
EID of the result in the Scopus database
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