Modified cyclopentadienyl molybdenum compounds with enhanced cytotoxic activity towards MOLT-4 leukaemia cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F17%3A39910838" target="_blank" >RIV/00216275:25310/17:39910838 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/17:10367221
Result on the web
<a href="http://dx.doi.org/10.1002/aoc.3759" target="_blank" >http://dx.doi.org/10.1002/aoc.3759</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/aoc.3759" target="_blank" >10.1002/aoc.3759</a>
Alternative languages
Result language
angličtina
Original language name
Modified cyclopentadienyl molybdenum compounds with enhanced cytotoxic activity towards MOLT-4 leukaemia cells
Original language description
A series of new cyclopentadienyl molybdenum compounds bearing substituted phenanthroline ligands [(eta(5)-C5H4CH2C6H4X-4)Mo(CO)(2)(L-N,L-N)][BF4] (X = F, Cl, Br; L-N,L-N=phen, 5-NH2-phen, 4,7-Ph-2-phen) was prepared and characterized using infrared and NMR spectroscopies. Crystal structures of [(eta(5)-C5H4CH2C6H4F-4)Mo(CO)(2)(NCMe)(2)][BF4], [(eta(5)-C5H4CH2C6H4X-4)Mo(CO)(2)(phen)][BF4] (X = F, Cl, Br) and [(eta(5)-C5H4CH2C6H4Cl-4)Mo(CO)(2)(4,7-Ph-2-phen)][BF4](4,7-Ph-2-phen)HBF4 were determined using X-ray diffraction analysis. Biological studies revealed a strong cytotoxic effect of the chelating ligands. Although the cytostatic effect of the halogen in the side chain of the cyclopentadienyl ring is negligible, it could be used for future post-modification of these types of cytotoxic active molybdenum-based compounds.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Applied Organometallic Chemistry
ISSN
0268-2605
e-ISSN
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Volume of the periodical
31
Issue of the periodical within the volume
11
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
"e3759-1"-"e3759-10"
UT code for WoS article
000413765100018
EID of the result in the Scopus database
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