The effect of substitution on the cytotoxicity of molybdenum(II) and tungsten(II) compounds

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F12%3A39894588" target="_blank" >RIV/00216275:25310/12:39894588 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/12:10124994
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0022328X12004317" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0022328X12004317</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jorganchem.2012.07.011" target="_blank" >10.1016/j.jorganchem.2012.07.011</a>

Result language
angličtina
Original language name
The effect of substitution on the cytotoxicity of molybdenum(II) and tungsten(II) compounds
Original language description
A series of allyl molybdenum [(eta(3)-C3H5)Mo(CO)(2)L2Cl], [(eta(3)-C3H4COOMe)Mo(CO)(2)L2Br], cyclopentadienyl molybdenum [(eta(5)-C5H4R)Mo(CO)(2)L-2][BF4] (R = H, 4-MeOC6H4CH2, 3,4,5-(MeO)(3)C6H2CH2), indenyl molybdenum [(eta(5)-C9H6R)Mo(CO)(2)L-2][BF4](R = H, 4-MeOC6H4CH2) and cyclopentadienyl tungsten compounds [(eta(5)-C5H5)W(CO)(2)L-2][BF4], where L-2 is N,N''-chelating ligand, were synthesized and characterized. The in vitro assay on human leukemia cells MOLT-4 has shown that the substitution inthe p-ligand has lower effect of on cytotoxicity than exchange of the N,N''-chelating ligand. Nevertheless, even this modification can lead to considerable enhance of cytotoxicity as was evidenced on the series of the indenyl molybdenum(II) compounds.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
—

Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)