Cyclopentadienyl Molybdenum(II) Compounds Bearing Ether and Thioether Functions in the Side Chain: Synthesis, Characterization, and Cytotoxic/Cytostatic Studies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F23%3A39920461" target="_blank" >RIV/00216275:25310/23:39920461 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/23:10468149
Result on the web
<a href="https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cplu.202300374" target="_blank" >https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cplu.202300374</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cplu.202300374" target="_blank" >10.1002/cplu.202300374</a>
Alternative languages
Result language
angličtina
Original language name
Cyclopentadienyl Molybdenum(II) Compounds Bearing Ether and Thioether Functions in the Side Chain: Synthesis, Characterization, and Cytotoxic/Cytostatic Studies
Original language description
A series of molybdenum(II) compounds [(& eta;5-Cp')Mo(CO)2(L2)][BF4] (Cp'=C5H4(CH2)2SPh, C9H6(CH2)2OMe, L2=N,N-chelating ligand) have been synthesized and characterized by spectroscopic and analytical methods including X-ray crystallography. The in vitro assay on human leukemia cells MOLT-4 has shown that the substitution in the & pi;-ligand in combination with suitable N,N-chelating ligand can lead to species with cytotoxicity considerably higher than reported to cisplatin. Unusually high activity was observed for compounds bearing phenanthroline ligands [{& eta;5-C9H6(CH2)2OMe}Mo(CO)2(3,4,7,8-Me4phen)][BF4] (IC50=0.7 & PLUSMN;0.3 & mu;M) and [{& eta;5-C9H6(CH2)2OMe}Mo(CO)2(4,7-Ph2phen)][BF4] (IC50 values 0.8 & PLUSMN;0.4 & mu;M). A series of cyclopentadienyl and indenyl molybdenum(II) compounds bearing N,N-chelating ligands has been synthesized and characterized by analytical methods including X-ray crystallography. Considerably enhanced cytotoxicity toward T-lymphocytic leukemia cells MOLT-4 was observed for derivatives bearing ether and thioether ligands. Species bearing phenanthroline ligands 3,4,7,8-Me4phen and 4,7-Ph2phen exhibit activity more than 20 times stronger than cisplatin.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ChemPlusChem
ISSN
2192-6506
e-ISSN
2192-6506
Volume of the periodical
88
Issue of the periodical within the volume
9
Country of publishing house
DE - GERMANY
Number of pages
11
Pages from-to
"e202300374"
UT code for WoS article
001060062200001
EID of the result in the Scopus database
2-s2.0-85169838859