A New Approach to the Dissolution Tests Management to Obtain Kinetic and Thermodynamic Data: Release of a Model Drug from Glyceryl Behenate Matrix Tablets
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F21%3A39918263" target="_blank" >RIV/00216275:25310/21:39918263 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/21:10433670
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/ejlt.202000235" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/ejlt.202000235</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ejlt.202000235" target="_blank" >10.1002/ejlt.202000235</a>
Alternative languages
Result language
angličtina
Original language name
A New Approach to the Dissolution Tests Management to Obtain Kinetic and Thermodynamic Data: Release of a Model Drug from Glyceryl Behenate Matrix Tablets
Original language description
This study is focused on the use of glyceryl behenate as a lipophilic excipient of matrix tablets providing controlled drug release. The aim of this study is to evaluate activation energy (EA) and changes of the thermodynamic parameters (Delta H, Delta S, Delta G) of a dissolution process. These values, which have not yet been published, can lead to better understanding of a drug release mechanism and can extend the use options of glyceryl behenate in the pharmaceutical industry. Values of Delta H, Delta S, Delta G and E-A, providing an overall thermodynamic view on the studied matrix tablets, are evaluated based on the temperature-dependences of the release rate constant of a model drug (temperature range 25 - 45 degrees C). The studied lipophilic matrix tablets contain 10% to 50% of glyceryl behenate. Dissolution testing is carried out in an aqueous solution of HCl with addition of NaCl (pH1.2). Positive values of Delta H in the range of 3.83 to 56.13 kJ mol(-1) and positive values of Delta G indicate that the dissolution of the studied glyceryl behenate matrix tablets is an endothermic process which does not proceed spontaneously (in a temperature range of 25 - 45 degrees C). The negative slope of the linear curves of enthalpy-entropy compensation confirms the entropy-driven dissolution.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Lipid Science and Technology
ISSN
1438-7697
e-ISSN
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Volume of the periodical
123
Issue of the periodical within the volume
5
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
"2000235-1"-"2000235-8"
UT code for WoS article
000635804700001
EID of the result in the Scopus database
2-s2.0-85103427619