Psychotomimetic Agent BZ (3-quinuclidinyl benzilate)
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25520%2F20%3A39917090" target="_blank" >RIV/00216275:25520/20:39917090 - isvavai.cz</a>
Result on the web
<a href="https://www.elsevier.com/books/handbook-of-toxicology-of-chemical-warfare-agents/gupta/978-0-12-819090-6" target="_blank" >https://www.elsevier.com/books/handbook-of-toxicology-of-chemical-warfare-agents/gupta/978-0-12-819090-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/B978-0-12-819090-6.00014-3" target="_blank" >10.1016/B978-0-12-819090-6.00014-3</a>
Alternative languages
Result language
angličtina
Original language name
Psychotomimetic Agent BZ (3-quinuclidinyl benzilate)
Original language description
BZ agent is the code for 3-quinuclidinyl benzilate, a psychotomimetic chemical warfare agent belonging to the family of anticholinergic hallucinogens. BZ is a competitive inhibitor of acetylcholine acting at the postsynaptic muscarinic receptors. Low doses of BZ are able to induce severe and long term anticholinergic psychotomimetics effect. The effect is characterized as vegetative symptoms progressing into confusion, hallucinations and other psychotic symptoms. The mechanism of action is based on BZ interaction with cholinergic receptors in the central and peripheral nervous system, resulting to lack of neuromediator acetylcholine. Antidotal effect against BZ intoxication is based on an increase of acetylcholine levels using reversible cholinesterase inhibitors. Physostigmine was historically used as an antidote against BZ. However, physostigmine has been omitted due to high toxicity and severe side effects and replaced by advanced cholinesterase inhibitors, including e.g. acridine derivatives. From these compounds, 7-methoxytacrine was the one of widely investigated potential antidotes.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Handbook of Toxicology of Chemical Warfare Agents
ISBN
978-0-12-819090-6
Number of pages of the result
11
Pages from-to
203-213
Number of pages of the book
1318
Publisher name
Academic Press (Elsevier)
Place of publication
Cambridge
UT code for WoS chapter
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