Mass Spectrometry of Heavy Analytes and Large Biological Aggregates by Monitoring Changes in the Quality Factor of Nanomechanical Resonators in Air

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F20%3APU136929" target="_blank" >RIV/00216305:26210/20:PU136929 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/20:10426396 RIV/68378271:_____/20:00563767

Result on the web

<a href="https://pubs.acs.org/doi/10.1021/acssensors.0c00756" target="_blank" >https://pubs.acs.org/doi/10.1021/acssensors.0c00756</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acssensors.0c00756" target="_blank" >10.1021/acssensors.0c00756</a>

Result language

angličtina

Original language name

Mass Spectrometry of Heavy Analytes and Large Biological Aggregates by Monitoring Changes in the Quality Factor of Nanomechanical Resonators in Air

Original language description

Nanomechanical resonators are routinely used for identification of various analytes like biological and chemical molecules, viruses or bacteria cells from the frequency response. This identification based on the multimode frequency shift measurement is limited to analyte of mass that is much lighter than the resonator mass; hence the analyte can be modeled as a point particle and, as such, its stiffness and nontrivial binding effects like surface stress can be neglected. For heavy analytes (> MDa) this identification, however, leads to incorrectly estimated masses. Here, by using a well-known frequency response of the nanomechanical resonator in air, we show that the heavy analyte can be identified without a need for highly challenging analysis of the analyte position, stiffness and/or binding effects just by monitoring changes in quality factor of a single harmonic frequency. Theory with a detailed procedure of mass extraction from quality factor is developed. In air, the quality factor depends on analyte mass and known air damping, while impact of the intrinsic dissipation is negligibly small. We find that the highest mass sensitivity (for considered resonator dimensions ~zg) can be achieved for rarely measured lateral mode, whereas the commonly detected flexural mode yields the lowest sensitivity. Validity of proposed procedure is confirmed by extracting mass of heavy analytes (GDa) made of protein and E. coli bacteria cells, and the ragweed pollen nanoparticle adsorbed on surface of the nanomechanical resonator(s) in air, of which the required changes in quality factor were previously experimentally measured, and by using numerical simulations. Our results open a doorway for rapid detection of viruses and bacteria cells using standard nanomechanical mass sensors.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

21001 - Nano-materials (production and properties)

Project

<a href="/en/project/GA17-08153S" target="_blank" >GA17-08153S: Novel material architectures for SMART piezoceramic electromechanical converters</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ACS Sensors

ISSN

2379-3694

e-ISSN

—

Volume of the periodical

5

Issue of the periodical within the volume

7

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

2128-2135

UT code for WoS article

000573554900034

EID of the result in the Scopus database

2-s2.0-85088608259