Resolving measurement of large (similar to GDa) chemical/biomolecule complexes with multimode nanomechanical resonators

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F22%3APU143664" target="_blank" >RIV/00216305:26210/22:PU143664 - isvavai.cz</a>

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0925400521016300?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0925400521016300?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.snb.2021.131062" target="_blank" >10.1016/j.snb.2021.131062</a>

Result language

angličtina

Original language name

Resolving measurement of large (similar to GDa) chemical/biomolecule complexes with multimode nanomechanical resonators

Original language description

Mass sensing by nanomechanical resonators can be routinely performed for analytes of mass ranging from kDa to tens of MDa. Measurement of the heavier analytes (up to hundreds of GDa) that are relevant to viruses, and many biological and chemical complexes, still remains one of the main challenges to be solved. Some studies propose the heavy analyte identification by accounting for its mass, stiffness and binding effects. However, the necessity of using the sophisticated computational tools complicates their widespread use in the nanomechanical mass spectrometry. Here, we report on the heavy analyte mass spectrometry (similar to GDa) using the multimode nanomechanical resonators, which is directly applicable to analytes of arbitrary mass, stiffness and dimensions. This identification, based on the simultaneous measurement of the multiple by analyte induced resonant frequency shifts, only requires the analyte to resonator mass ratio between 0.001 and 0.02. We show that the analyte stiffness and binding effects must be considered for the lower mass ratios (< 0.001), while for the higher mass ratios (> 0.02) the inaccuracies in determined mass are independent of both the analyte stiffness and binding effects, and increase with the mass of analyte. Validity of present results have been demonstrated by comparing predictions with the recent experimental measurements performed on the micro-/nanomechanical resonator-based mass spectrometers. Our findings, together with the provided software, which enables an easily accessible determination of the effects of analyte properties on the frequency response, present a novel paradigm in a design of the nanomechanical resonators for mass sensing in GDa range.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

21101 - Food and beverages

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Sensors and Actuators B: Chemical

ISSN

0925-4005

e-ISSN

—

Volume of the periodical

353

Issue of the periodical within the volume

15

Country of publishing house

CH - SWITZERLAND

Number of pages

9

Pages from-to

1-9

UT code for WoS article

000744546700004

EID of the result in the Scopus database

2-s2.0-85119903426