Analysis of Dynamic Changes in ECG Signals During Optical Mapping By Dynamic Time Warping

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F05%3APU50088" target="_blank" >RIV/00216305:26220/05:PU50088 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Analysis of Dynamic Changes in ECG Signals During Optical Mapping By Dynamic Time Warping

Original language description

Voltage-sensitive dyes (VSDs) are used in touch-less recording of electrical activity from animal hearts. VSD's undergo changes in their fluorescence spectra, in response to changes in the surrounding electric field. This optical response is sufficientlyfast to detect transient potential changes in excitable cardiac cells. However, our previous Langendorf perfused heart studies have suggested changes in ECG signals in time and time-frequency domain caused by application of VSD during optical mapping. DDetailed analysis of changes is needed to reveal impact to particular fractions of a heart cycle. Rabbit hearts are employed in our laboratory to record monophasic action potentials using VSDs in isolated hearts perfused according to Langendorf. The spontaneously beating heart is mounted on Langendorf set and perfused with constant perfusion pressure with Krebs-Henseleit solution (37°C, 1,25mM Ca2+). After control period (20 min), the heart is loaded with di-4-ANEPPS (2uM) diluted in per

Czech name

Analysis of Dynamic Changes in ECG Signals During Optical Mapping By Dynamic Time Warping

Czech description

Voltage-sensitive dyes (VSDs) are used in touch-less recording of electrical activity from animal hearts. VSD's undergo changes in their fluorescence spectra, in response to changes in the surrounding electric field. This optical response is sufficientlyfast to detect transient potential changes in excitable cardiac cells. However, our previous Langendorf perfused heart studies have suggested changes in ECG signals in time and time-frequency domain caused by application of VSD during optical mapping. DDetailed analysis of changes is needed to reveal impact to particular fractions of a heart cycle. Rabbit hearts are employed in our laboratory to record monophasic action potentials using VSDs in isolated hearts perfused according to Langendorf. The spontaneously beating heart is mounted on Langendorf set and perfused with constant perfusion pressure with Krebs-Henseleit solution (37°C, 1,25mM Ca2+). After control period (20 min), the heart is loaded with di-4-ANEPPS (2uM) diluted in per

Type

D - Article in proceedings

CEP classification

JD - Use of computers, robotics and its application

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2005

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Computers in Cardiology

ISBN

0-7803-8894-1

ISSN

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e-ISSN

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Number of pages

4

Pages from-to

1-4

Publisher name

IEEE

Place of publication

Francie

Event location

Lyon

Event date

Sep 25, 2005

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

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