An Aditional Marker of Ventricular Dyssynchrony

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F15%3APU115364" target="_blank" >RIV/00216305:26220/15:PU115364 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1109/CIC.2015.7408590" target="_blank" >http://dx.doi.org/10.1109/CIC.2015.7408590</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1109/CIC.2015.7408590" target="_blank" >10.1109/CIC.2015.7408590</a>

Result language
angličtina
Original language name
An Aditional Marker of Ventricular Dyssynchrony
Original language description
Patients suffering from left bundle branch block (LBBB) can be treated by resynchronization therapy (CRT). The QRS duration (QRSd) and QRS morphology are the main selection criteria. Unfortunately, approximately one-third of CRT patients are non-responders. Here we introduce an additional marker capable of distinguishing ventricular dyssynchrony more accurately. Methods: Ultra-high-frequency (UHF, sampling 25kHz) 12-lead ECG, 15-minute resting supine position, was measured. We analyzed 21 LBBB patients selected for CRT, the QRSd min/mean/max was 130/163/190 ms. Amplitude envelopes in the 500-1000 Hz passband were computed and averaged with R-wave trigger for each patient in V1 and V6 leads. V1-V6 dyssynchrony (DYS) was computed as the time difference between UHF amplitude maximums in the V1 and V6 QRS complex region. Results: The DYS parameter min/mean/max was 1/68/115 ms. Patients with a small value of the DYS parameter, in spite of its QRS duration meet CRT criteria (>120 ms), are not expected CRT responders. The DYS parameter indicates ventricular dyssynchrony and can potentially increase the percentage of CRT responders.
Czech name
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Czech description
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Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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