Using ASL Method for Monitoring of Brain Perfusion Changes in a Rat Model of Schizophrenia and after Chronic Administration of Aripiprazole
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F15%3APU115643" target="_blank" >RIV/00216305:26220/15:PU115643 - isvavai.cz</a>
Alternative codes found
RIV/68081731:_____/15:00446112 RIV/00216224:14110/15:00095810
Result on the web
<a href="http://www.measurement.sk/M2015/" target="_blank" >http://www.measurement.sk/M2015/</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Using ASL Method for Monitoring of Brain Perfusion Changes in a Rat Model of Schizophrenia and after Chronic Administration of Aripiprazole
Original language description
Animals prenatally exposed to polyriboinosinic?polyribocytidilic acid (poly I:C) can be used to parallel neuropathological abnormalities seen in schizophrenia patients. The aim of this study was to test the utility of Arterial Spin Labeling (ASL) MRI method for the evaluation of perfusion in different brain regions in the developmental poly I:C model of schizophrenia in rats. In these animals we further investigated the effect of chronic administration of the antipsychotic aripiprazole on brain perfusion. In the circle of Willis region, we observed significant (p<0,05) increase of blood perfusion in the poly I:C model of schizophrenia in both males and females, and significantly higher perfusion in males than in females in vehicle-treated controls. Perfusion in hippocampus (in both hemispheres) was found significantly higher in males than in females in both vehicle-treated controls and poly I:C prenatally exposed animals. The significantly increased blood perfusion in the circle of Wil
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
EI - Biotechnology and bionics
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
10th International Conference on Measurement
ISBN
978-80-969672-9-2
ISSN
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e-ISSN
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Number of pages
4
Pages from-to
81-84
Publisher name
Institute of Measurement Science
Place of publication
Bratislava
Event location
Smolenice
Event date
May 25, 2015
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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