Poly(I:C) model of schizophrenia in rats induces sex-dependent functional brain changes detected by MRI that are not reversed by aripiprazole treatment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F18%3A43876744" target="_blank" >RIV/62157124:16370/18:43876744 - isvavai.cz</a>
Alternative codes found
RIV/68081731:_____/18:00489601 RIV/00216224:14110/18:00102121 RIV/65269705:_____/18:00068541
Result on the web
<a href="https://reader.elsevier.com/reader/sd/pii/S0361923017305828?token=FD89FE81B5199B092D887A4BD53C60D6CDDB35F512F1A12A80672CB1D32CCB1CEC54E0D8FC3937055BA77BB5A99BFA1F" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0361923017305828?token=FD89FE81B5199B092D887A4BD53C60D6CDDB35F512F1A12A80672CB1D32CCB1CEC54E0D8FC3937055BA77BB5A99BFA1F</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.brainresbull.2017.11.008" target="_blank" >10.1016/j.brainresbull.2017.11.008</a>
Alternative languages
Result language
angličtina
Original language name
Poly(I:C) model of schizophrenia in rats induces sex-dependent functional brain changes detected by MRI that are not reversed by aripiprazole treatment
Original language description
Background and purpose: One of the hallmarks of schizophrenia is altered brain structure, potentially due to antipsychotic treatment, the disorder itself or both. It was proposed that functional changes may precede the structural ones. In order to understand and potentially prevent this unwanted process, brain function assessment should be validated as a diagnostic tool. Methods: We used Arterial Spin Labelling MRI technique for the evaluation of brain perfusion in several brain regions in a neurodevelopmental poly(I:C) model of schizophrenia (8 mg/kg on a gestational day 15) in rats taking into account sex-dependent effects and chronic treatment with aripiprazole (30 days), an atypical anti psychotic acting as a partial agonist on dopaminergic receptors. Results: We found the sex of the animal to have a highly significant effect in all regions of interest, with females showing lower blood perfusion than males. However, both males and females treated prenatally with poly(I:C) showed enlargement of the lateral ventricles. Furthermore, we detected increased perfusion in the circle of Willis, hippocampus, and sensorimotor cortex, which was not influenced by chronic atypical antipsychotic aripiprazole treatment in male poly(I:C) rats. Conclusion: We hypothesize that perfusion alterations may be caused by the hyperdopaminergic activity in the poly(I:C) model, and the absence of aripiprazole effect on perfusion in brain regions related to schizophrenia may be due to its partial agonistic mechanism.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Brain Research Bulletin
ISSN
0361-9230
e-ISSN
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Volume of the periodical
137
Issue of the periodical within the volume
March 2018
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
146-155
UT code for WoS article
000427344300016
EID of the result in the Scopus database
2-s2.0-85035792877