Comparison of Mathematical and Controlled Mechanical Lung Simulation in Active Breathing and Ventilated State

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F18%3APU127859" target="_blank" >RIV/00216305:26220/18:PU127859 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.ifacol.2018.07.127" target="_blank" >http://dx.doi.org/10.1016/j.ifacol.2018.07.127</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ifacol.2018.07.127" target="_blank" >10.1016/j.ifacol.2018.07.127</a>

Result language

angličtina

Original language name

Comparison of Mathematical and Controlled Mechanical Lung Simulation in Active Breathing and Ventilated State

Original language description

Respiratory diseases are ubiquitous among European citizens and their prevalence is increasing steadily. Deeper insight into the respiratory process can be gained by modelling of the region of interest in the human body. The presented lung simulator xPULM bridges the gap between in-silico (mathematical), in-vivo (cell culture based) and mechanical models of the respiratory tract. By adopting selected mathematical models of the human respiratory tract two scenarios were simulated. The linear mathematical single compartment model was used for simulation of the human breathing pattern at rest. Higher complexity non-linear mathematical model reflecting diverse nature of the human respiratory tract was used as a basis for simulation of an artificially ventilated patient. The time-flow characteristics of the mathematical models have been implemented into the control software of the mechanical lung simulator - xPULM. The simulator was then configured to replicate these required breathing patterns employing feedback control loop. The airflow was measured over the course of breathing simulation. The results show high conformity of required and measured breathing patterns characteristic with steady frequency rate and minimal airflow variability. Furthermore, xPULM was capable of reproducing rapid changes of airflow occurring during simulation of artificially ventilated patient, showing high versatility and adaptability of the simulator. Future research will focus on reduction of flow fluctuations and implementation of new breathing patterns. (C) 2018, IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. All rights reserved.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

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OECD FORD branch

20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Proceedings of the 15th IFAC Conference on Programmable Devices and Embedded Systems PDeS 2018

ISBN

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ISSN

2405-8963

e-ISSN

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Number of pages

6

Pages from-to

42-47

Publisher name

Neuveden

Place of publication

neuveden

Event location

Ostrava

Event date

May 23, 2018

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

000445644900008