Electro-mechanical Lung Simulator Using Polymer and Organic Human Lung Equivalents for Realistic Breathing Simulation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F19%3APU135472" target="_blank" >RIV/00216305:26220/19:PU135472 - isvavai.cz</a>

Result on the web

<a href="https://www.nature.com/articles/s41598-019-56176-6#article-info" target="_blank" >https://www.nature.com/articles/s41598-019-56176-6#article-info</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-019-56176-6" target="_blank" >10.1038/s41598-019-56176-6</a>

Result language

angličtina

Original language name

Electro-mechanical Lung Simulator Using Polymer and Organic Human Lung Equivalents for Realistic Breathing Simulation

Original language description

Simulation models in respiratory research are increasingly used for medical product development and testing, especially because in-vivo models are coupled with a high degree of complexity and ethical concerns. This work introduces a respiratory simulation system, which is bridging the gap between the complex, real anatomical environment and the safe, cost-effective simulation methods. The presented electro-mechanical lung simulator, xPULM, combines in-silico, ex-vivo and mechanical respiratory approaches by realistically replicating an actively breathing human lung. The reproducibility of sinusoidal breathing simulations with xPULM was verified for selected breathing frequencies (10-18 bpm) and tidal volumes (400-600 ml) physiologically occurring during human breathing at rest. Human lung anatomy was modelled using latex bags and primed porcine lungs. High reproducibility of flow and pressure characteristics was shown by evaluating breathing cycles (n(Total) = 3273) with highest standard deviation vertical bar 3 sigma vertical bar for both, simplified lung equivalents (mu(V) = 23.98 +/- 1.04 l/min, mu(P) = -0.78 +/- 0.63 hPa) and primed porcine lungs (mu(V) = 18.87 +/- 2.49 l/min, mu(P) = -21.13 +/- 1.47 hPa). The adaptability of the breathing simulation parameters, coupled with the use of porcine lungs salvaged from a slaughterhouse process, represents an advancement towards anatomically and physiologically realistic modelling of human respiration.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10700 - Other natural sciences

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scientific Reports

ISSN

2045-2322

e-ISSN

—

Volume of the periodical

9

Issue of the periodical within the volume

9

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

1-12

UT code for WoS article

000508915900008

EID of the result in the Scopus database

—