Articulatory network reorganization in Parkinson's disease as assessed by multimodal MRI and acoustic measures

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F21%3APU139710" target="_blank" >RIV/00216305:26220/21:PU139710 - isvavai.cz</a>

Alternative codes found

RIV/00159816:_____/21:00074707 RIV/00216224:14740/21:00120169

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S1353802021000535" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1353802021000535</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.parkreldis.2021.02.012" target="_blank" >10.1016/j.parkreldis.2021.02.012</a>

Result language

angličtina

Original language name

Articulatory network reorganization in Parkinson's disease as assessed by multimodal MRI and acoustic measures

Original language description

Introduction: Hypokinetic dysarthria (HD) is common in Parkinson's disease (PD). Our objective was to evaluate articulatory networks and their reorganization due to PD pathology in individuals without overt speech impairment using a multimodal MRI protocol and acoustic analysis of speech. Methods: A total of 34 PD patients with no subjective HD complaints and 25 age-matched healthy controls (HC) underwent speech task recordings, structural MRI, and reading task-induced and resting-state fMRI. Grey matter probability maps, task-induced activations, and resting-state functional connectivity within the regions engaged in speech production (ROIs) were assessed and compared between groups. Correlation with acoustic parameters was also performed. Results: PD patients as compared Tto HC displayed temporal decreases in speech loudness which were related to BOLD signal increases in the right-sided regions of the dorsal language pathway/articulatory network. Among those regions, activation of the right anterior cingulate was increased in PD as compared to HC. We also found bilateral posterior superior temporal gyrus (STG) GM loss in PD as compared to HC that was strongly associated with diadochokinetic (DDK) irregularity in the PD group. Task-induced activations of the left STG were increased in PD as compared to HC and were related to the DDK rate control. Conclusions: The results provide insight into the neural correlates of speech production control and distinct articulatory network reorganization in PD apparent already in patients without subjective speech impairment.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PARKINSONISM & RELATED DISORDERS

ISSN

1353-8020

e-ISSN

1873-5126

Volume of the periodical

84

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

122-128

UT code for WoS article

000632026700020

EID of the result in the Scopus database

2-s2.0-85101359663