FireProt 2.0
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26230%2F23%3APR37705" target="_blank" >RIV/00216305:26230/23:PR37705 - isvavai.cz</a>
Result on the web
<a href="https://www.fit.vut.cz/research/product/792/" target="_blank" >https://www.fit.vut.cz/research/product/792/</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
FireProt 2.0
Original language description
FireProt protocol enables the automated computational design of highly stable multiple-point mutants. FireProt 2.0 builds on top of the previously published FireProt web, retaining the original functionality and expanding it with several new stabilization strategies. FireProt 2.0 integrates the AlphaFold database and the homology modelling for structure prediction, enabling calculations starting from a sequence. Multiple-point designs are constructed using the Bron-Kerbosch algorithm minimizing the antagonistic effect between the individual mutations. Users can newly limit the FireProt calculation to a set of user-defined mutations, run a saturation mutagenesis of the whole protein, or select rigidifying mutations based on B-factors. Evolution-based back-to-consensus strategy is complemented by ancestral sequence reconstruction. FireProt 2.0 is significantly faster and a reworked graphical user interface broadens the tool's availability even to users with older hardware.
Czech name
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Czech description
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Classification
Type
R - Software
CEP classification
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OECD FORD branch
10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Internal product ID
FireProt
Technical parameters
Pro informace o licenčních podmínkách prosím kontaktujte: Mgr. Radka Báčová, Výzkumné centrum informačních technologií, Fakulta informačních technologií VUT v Brně, Božetěchova 2, 612 66 Brno, 541 141 473.
Economical parameters
Nástroj je volně dostupný pro akademickou komunitu. Nelze použít pro komerční účely (z důvodu ochrany práv třetích stran - několika integrovaných metod s nesvobodnou licencí).
Owner IČO
00216224
Owner name
Masarykova Univerzita v Brně