Study of nanoparticles formed by cationic micelles and hyaluronan

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F15%3APU115810" target="_blank" >RIV/00216305:26310/15:PU115810 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Study of nanoparticles formed by cationic micelles and hyaluronan
Original language description
Hyaluronan as negatively charged polyelectrolyte can interact with positively charged surfactant micelles via electrostatic interactions to form core-shell like nanoparticles. These aggregates can solubilize hydrophobic active substances and therefore are potential carriers in drug delivery applications. This research was conducted with the aim to prepare nanoparticles consisting of hyaluronan and cationic micelles and evaluate strength of electrostatic interactions between components. Interactions of hyaluronan and surfactants in aqueous solution were investigated using turbidimetry method and stability of nanoparticles was studied using dialysis technique. Turbidimetric titration was chosen as indicator of the loss of intensity of transmitted light due to the scattering effect of particles associated from hyaluronan and surfactant in it. Results of turbidimetry revealed that aggregates formation depends on hyaluronan concentration while surfactant concentration (above critical micell
Czech name
—
Czech description
—

Project
<a href="/en/project/LO1211" target="_blank" >LO1211: Materials Research Centre at FCH BUT- Sustainability and Development</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)