Study of nanoparticles formed by cationic micelles and hyaluronan

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F15%3APU119903" target="_blank" >RIV/00216305:26310/15:PU119903 - isvavai.cz</a>

Result on the web

<a href="http://www.nanocon.eu/files/proceedings/23/papers/4232.pdf" target="_blank" >http://www.nanocon.eu/files/proceedings/23/papers/4232.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Study of nanoparticles formed by cationic micelles and hyaluronan

Original language description

Hyaluronan as negatively charged polyelectrolyte can interact with positively charged surfactant micelles via electrostatic interactions to form core-shell like nanoparticles. These aggregates can solubilize hydrophobic active substances and therefore are potential carriers in drug delivery applications. This research was conducted with the aim to prepare nanoparticles consisting of hyaluronan and cationic micelles and evaluate strength of electrostatic interactions between components. Interactions of hyaluronan and surfactants in aqueous solution were investigated using turbidimetry method and stability of nanoparticles was studied using dialysis technique. Turbidimetric titration was chosen as indicator of the loss of intensity of transmitted light due to the scattering effect of particles associated from hyaluronan and surfactant in it. Results of turbidimetry revealed that aggregates formation depends on hyaluronan concentration while surfactant concentration (above critical micelle concentration) affects interaction insignificantly. On the basis of turbidimetric results a system for dialysis experiments was selected. Dialysis experiments showed that a part of surfactant molecules is bound to hyaluronan chain and a rest of molecules diffuse to water through dialysis membrane and after a lapse of time the concentrations of the retentate and permeate were balanced. The system can be suitable for the preparation of targeted carriers of biologically active substances.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

CF - Physical chemistry and theoretical chemistry

OECD FORD branch

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Project

<a href="/en/project/LO1211" target="_blank" >LO1211: Materials Research Centre at FCH BUT- Sustainability and Development</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

NANOCON 2015 Conference Proceedings

ISBN

978-80-87294-63-5

ISSN

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e-ISSN

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Number of pages

4

Pages from-to

404-407

Publisher name

TANGER Ltd

Place of publication

Ostrava

Event location

Brno

Event date

Oct 14, 2015

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

000374708800071