Turbidimetry and fluorescence study of hyaluronan-surfactant nanoparticles formation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F17%3APU136157" target="_blank" >RIV/00216305:26310/17:PU136157 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Turbidimetry and fluorescence study of hyaluronan-surfactant nanoparticles formation

Original language description

This paper deals with electrostatic association of cationic micelles (CTAB or Septonex) with hyaluronan. Hyaluronan as negatively charged polyelectrolyte can interact with positively charged surfactant micelles via electrostatic interactions to form nano-core-shell like aggregates. These self-assembly nanoparticles can solubilize hydrophobic active substances and therefore, they are potential carriers in drug delivery applications. The cationic micelle/hyaluronan complexes were studied using turbidimetry and fluorescence spectroscopy method. Turbidimetric titration was chosen as an indicator of component aggregation which is related to the loss of transmitted light intensity due to the scattering effect. Fluorescent probe pyrene was selected for spectroscopy experiments because of its unique sensitivity to polarity of the medium, so this fluorescence method was used as an indicator of presence of hydrophobic domains in the system. Effect of components concentration and molecular weight of hyaluronan were evaluated. Results of turbidimetry revealed that aggregates formation (turbidity increasing) depends especially on a charge ratio of surfactant molecules and hyaluronan carboxyl groups. It was found a difference in association of low molecular weight and high molecular weight of hyaluronan. Fluorescence results confirmed presence and stability of micellar aggregates in studied systems.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

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OECD FORD branch

10403 - Physical chemistry

Project

<a href="/en/project/LO1211" target="_blank" >LO1211: Materials Research Centre at FCH BUT- Sustainability and Development</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

8TH INTERNATIONAL CONFERENCE ON NANOMATERIALS - RESEARCH & APPLICATION (NANOCON 2016)

ISBN

978-80-87294-71-0

ISSN

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e-ISSN

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Number of pages

5

Pages from-to

439-443

Publisher name

Tanger, s.r.o.

Place of publication

Ostrava

Event location

Brno

Event date

Oct 19, 2016

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

000410656100077