CHARACTERIZATION OF NANOFIBER AND HYDROGEL WOUND DRESSINGS

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F21%3APU142563" target="_blank" >RIV/00216305:26310/21:PU142563 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
CHARACTERIZATION OF NANOFIBER AND HYDROGEL WOUND DRESSINGS
Original language description
The primary function of the wound dressings has been to clean, cover and protect the wound from external environment. They have been applied on injured areas to provide moist environment, protect the wound from infection, remove excess of exudate, avoid maceration and maintain sufficient exchange of gases. The aim of this study was to prepare and characterize bioactive hydrogel and nanofiber wound dressings functionalized by broad spectrum antibiotic drug, ampicillin. Nanostructures were constituted from poly(3- hydroxybutyrate) and hydrogels were alginate and chitosan based. Nanofibers were assembled by electrospinning and force spinning techniques and their morphology was confirmed by scanning electron microscopy. Prepared materials were analysed for gradual releasing of the incorporated substance into model environments using spectrophotometric methods. Antibacterial activity against model gram-positive (M. luteus) and gram-negative (S. epidermidis, E. coli) bacterial strains was also evaluated. Th
Czech name
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Czech description
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Type
O - Miscellaneous
CEP classification
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OECD FORD branch
30404 - Biomaterials (as related to medical implants, devices, sensors)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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