Identification of estrogen receptor proteins in breast cancer cells using matrix assisted laser desorption/ionization time of flight mass spectrometry (Review)

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F14%3APU108610" target="_blank" >RIV/00216305:26620/14:PU108610 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3892/ol.2014.1912" target="_blank" >http://dx.doi.org/10.3892/ol.2014.1912</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3892/ol.2014.1912" target="_blank" >10.3892/ol.2014.1912</a>

Result language
angličtina
Original language name
Identification of estrogen receptor proteins in breast cancer cells using matrix assisted laser desorption/ionization time of flight mass spectrometry (Review)
Original language description
Estrogen receptors [ERs (subtypes alfa and beta)], classified as a nuclear receptor super family, are intracellular proteins with an important biological role as the transcription factors for estrogen target genes. For ER induced transcription, an interaction must exist between ligand and coregulators. Coregulators may stimulate (coactivators) or inhibit (corepressors) transcription, following binding with a specific region of the gene, called the estrogen response element. Misbalanced activity of coregulators or higher ligand concentrations may cause increased cell proliferation, resulting in specific types of cancer. These are exhibited as overexpression of ER proteins. Breast cancer currently ranks first in the incidence and second in the mortality of cancer in females worldwide. In addition, 70% of breast tumors are ER alfa positive and the importance of these proteins for diagnostic use is indisputable. Early diagnosis of the tumor and its classification has a large influence on the selection of appropriate therapy, as ER positive tumors demonstrate a positive response to hormonal therapy.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)

Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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